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Updated: Jun 21, 2025

Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae
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Published on: September 11, 2022

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RNA 2'-O-甲基化促进了持续的R循环形成和AID介导的IgH类开关重组

Muzaffer Ahmad Kassab1,2, Yibin Chen3,4, Xin Wang3,5

  • 1Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA, 91010, USA. muzaffer.kassab@pennmedicine.upenn.edu.

BMC biology
|July 8, 2024
PubMed
概括

рибо2'-O-甲基化 (2'-OMe) 在免疫球蛋白重链位点稳定了RNA-DNA杂交物 (R-环),促进了免疫球蛋白类开关重组 (CSR). 这种修饰是通过纤维拉林 (FBL) 与激活诱导的细胞氨酸脱氨酶 (AID) 和snoRNAaSNORD1C.C.相互作用来促进的.

关键词:
2'-O-甲基化 (2'-OMe) 的方法激活诱导的cytidine除氨酶 (AID) 的使用类切换重组 (CSR) 是一种类切换重组技术.这是一个R环.

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