对空气污染的短期和长期暴露对内皮功能障碍的影响的年龄和性别差异
Haoyu Zhang1, Jing Yang1, Yinghua Zhang2
1Department of Geriatrics, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
概括
空气污染,包括细颗粒物 (PM2.5) 和PM10,显著损害内皮功能,通过流媒扩张 (FMD) 测量. 对这些影响的敏感性因年龄和性别而异,男性和年轻人表现出更大的脆弱性.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 毒理学 毒理学 毒理学
背景情况:
- 内皮功能障碍是心血管疾病的关键因素.
- 环境空气污染对内皮功能的影响在不同人群中尚未完全理解.
- 支臂动脉流媒扩张 (FMD) 是对内皮功能的一种验证测量方法.
研究的目的:
- 调查暴露于各种空气污染物和内皮功能之间的关联.
- 为了确定人群差异,特别是年龄和性别,对空气污染引起的内皮功能障碍的敏感性.
主要方法:
- 在2016年10月至2020年1月期间,在828名参与者中测量了口病.
- 使用环境空气监测数据评估了对PM2.5,PM10,SO2,NO2,CO和O3的短期和长期暴露.
- 进行了统计分析,包括多重线性回归和受限制的立方线,并按年龄和性别分层.
主要成果:
- 增加对PM2.5和PM10 (短期和长期) 的暴露显著与口炎的减少有关.
- 对所有测量的空气污染物的长期暴露与内皮功能受损有关.
- 空气污染和口炎减少之间的关联在男性和65岁以下的个人中比女性和老年人更明显.
结论:
- 短期和长期暴露于常见的空气污染物都会对内皮功能产生负面影响.
- 年龄和性别显著改变个人对空气污染对血管健康不利影响的敏感性.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
152
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
152