在以前吸烟的患者中发现推动肺腺癌异质性的分子特征
Peiyao Wang1,2, Raymond Ng3, Stephen Lam1
1Department of Integrative Oncology, BC Cancer Research Institute, 675 West 10th Avenue, Vancouver, BC, V5Z 1G1, Canada.
Journal of translational medicine
|July 8, 2024
概括
前吸烟者的肺腺癌 (LUAD) 呈现出明显的生物特征. 这些瘤中的基因表达特征可以预测预后并指导治疗选择,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 癌症研究 癌症研究
背景情况:
- 越来越多的肺腺癌 (LUAD) 病例发生在戒烟的人群中.
- 研究前吸烟者之间的LUAD分子差异对于理解疾病异质性至关重要.
研究的目的:
- 确定前吸烟者的烟草吸烟引起的LUAD分子变化是否与不同的生物和临床因素相关.
- 为了确定潜在的生物标志物用于预后和治疗选择在这个患者小组.
主要方法:
- 在LUAD患者 (从未吸烟者与目前吸烟者) 上使用随机森林模型开发了一种123基因的吸烟相关签名.
- 应用签名将以前吸烟 (FS) 的LUAD患者分为"目前吸烟者" (CS-like) 或"从未吸烟者" (NS-like) 组.
- 分析了分类与患者特征,瘤生物学 (突变负担,免疫细胞种群) 和临床结果之间的关联.
主要成果:
- 基因签名准确地分类了从未吸烟者和目前吸烟者 (AUC 0.85-0.92).
- 在TCGA队列中,以前吸烟的患者被分为CS类 (n=213) 或NS类 (n=86).
- 与CS型患者相比,NS型以前吸烟的LUAD患者的整体存活时间明显更长 (17.5-18.6个月长).
- 在CS类和NS类以前吸烟的LUAD之间观察到生物学差异,包括瘤突变负担和免疫细胞透.
结论:
- 以前吸烟的LUAD患者目前具有异质瘤生物学.
- 吸烟诱导的基因表达模式可以分层这些患者,提供预后信息.
- 这种分层可以根据潜在的生物特征制定个性化治疗策略.
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