探索术后高氧性间歇性刺激对癌症患者视网球细胞水平的影响:一项随机对照研究
Maher Khalife1, Michele Salvagno2, Maurice Sosnowski3
1Institut Jules Bordet, Anaesthesiology, H.U.B, Brussels, Belgium. maher.khalife@hubruxelles.be.
Journal of anesthesia, analgesia and critical care
|July 8, 2024
概括
诺莫巴里克氧疗法 (NOP) 显示出在手术后刺激癌症患者的红细胞生产的潜力. 这种疗法增加了网细胞计数,这表明在瘤学患者中治疗贫血的有希望的方法.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 在接受手术的住院癌症患者中,贫血很普遍.
- 增加的癌症发病率和治疗方法增加了对血液制品的需求.
- 诺莫巴里克氧悖论 (NOP) 正在探索如何提高红素蛋白 (EPO) 水平.
研究的目的:
- 评估NOP协议在刺激红色素形成中的有效性.
- 为了测量网细胞数量的变化,作为红色素形成的指标.
- 评估NOP对接受腹部手术的癌症患者的影响.
主要方法:
- 一个前性的,单中心的,随机对照研究的后期分析.
- 分析了49名腹部手术患者;33人被列入最终分析.
- 干预组在术后第1,3,5天接受了2小时的60%氧气;对照组接受了标准护理.
主要成果:
- 与对照组 (n=17) 相比,氧气组 (n=16) 的网细胞百分比显著增加 (p=0.0237).
- 氧气组中细胞网状细胞的中位数增加为36.1%,对照组为-5.3%.
- 两组之间没有观察到血红蛋白或血红素值变化的显著差异.
结论:
- 初步证据表明,NOP可能会刺激手术癌症患者的红色素形成.
- 在NOP组中增加的网细胞计数需要进一步调查.
- 需要进行更大规模的多中心试验来确认NOP的有效性.
更多相关视频
13:37A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
Published on: March 12, 2014
30.0K
09:48Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
13.8K
相关概念视频
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:24Factors Affecting Erythropoiesis
3.2K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.2K