2023年膝关节软骨缺陷的新型治疗选择
Claudia Ghisa1, Kenneth R Zaslav2
1Lenox Hill Hospital Northwell Orthopedic Institute.
Sports medicine and arthroscopy review
|July 9, 2024
概括
关节软骨病变的新疗法提供了创新的关节保护选择. 这些包括一个阿拉戈尼特支架,干细胞疗法,以及一种新的单阶段程序,将自异性chondrons与介质细胞干细胞结合起来.
科学领域:
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
- 生物材料科学是生物材料的科学.
背景情况:
- 关节软骨病变很常见,并且越来越多地可以通过关节保护来治疗.
- 现有的治疗方法包括全移植和细胞疗法.
- 对于复杂的软骨缺陷,需要新的方法.
研究的目的:
- 审查三种独特的,新兴的关节软骨病变治疗方案.
- 突出联合保存程序的进步.
- 讨论用于冠状体和骨冠状体缺陷的新疗法途径.
主要方法:
- 关于Agili-C的讨论:一种FDA/EMEA批准的以阿拉贡岩为基础的支架,用于带和骨带病变.
- 概述Cartistem:在美国临床试验中的干细胞疗法 (介质干细胞),在韩国获得批准.
- 在IMPACT和RECLAIM研究的基础上,介绍了一步程序,使用自主性chondrons和全原性介质干细胞 (MSCs).
主要成果:
- 阿吉利-C为各种带有或没有关节炎的软骨病变提供治疗.
- 卡蒂斯蒂姆作为一种基于干细胞的治疗方法具有前景,在韩国已经得到了广泛的应用.
- 这一一阶段的程序结合了自身的chondrons和MSCs证明了安全性和有效性.
结论:
- 关节软骨缺陷出现了多种新的治疗途径.
- 这些选择代表了各种策略,包括支架,细胞疗法和联合手术.
- 关节保护方面的进步为软骨损伤患者提供了新的希望.
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