术前tamsulosin对成功的尿路接入外套安置和支架相关症状缓解的影响:一项双盲,随机,安慰剂控制的双盲研究
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Updated: Jun 27, 2026

08:09
Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
11.4K
Kyeng Hyun Nam1, Jungyo Suh1, Jung Hyun Shin2
1Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Investigative and clinical urology
|July 9, 2024
概括
术前的坦苏洛辛显著提高了在手术期间更大的尿路接入 (UAS) 插入的成功率. 然而,tamsulosin在接受逆行性内外科手术的患者中没有缓解尿路支架症状.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 在逆行性内外科手术中,尿道接入 (UAS) 插入可能具有挑战性.
- 坦素是一种α阻断剂,有时用于促进尿路结石的通过,并可能影响手术程序.
研究的目的:
- 评估手术前的tamsulosin对成功插入12/14法国 (F) 尿道接入罩 (UAS) 的影响.
- 评估术前和术后的tamsulosin对尿道支架相关症状的影响.
主要方法:
- 一个随机的,单中心的,双盲的,安慰剂控制的试验与200名接受单边逆行性内外科手术的患者进行.
- 患者接受了tamsulosin或安慰剂从一周手术前,直到切除支架,与四个研究小组根据时间的管理.
- 尿道支架症状问卷 (USSQ) 用于在术后评估症状.
主要成果:
- 分析包括160名患者;48名 (30.0%) 是女性,平均年龄为55.0±11.0岁.
- 12/14F UAS部署的成功率在手术前的坦苏洛辛组 (88.0%) 与手术前的安慰剂组 (75.3%,p=0.038) 相比,在手术前的坦苏洛辛组显著更高.
- 在手术前和手术后,使用tamsulosin并没有显著减少与尿路支架相关的症状.
结论:
- 在手术前服用坦苏洛辛可提高在逆行性内外科手术中更大的UAS插入的成功率.
- 坦素的使用,无论时间 (手术前或手术后),都没有显示出在减轻尿路支架症状方面有显著的益处.
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