相关实验视频

Updated: Jun 21, 2025

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

多酶活性纳米酶通过调节免疫和炎症抑制来有效治疗败血症

Qi Xin^1,2, Shaofang Zhang¹, Si Sun³

¹Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.

ACS applied materials & interfaces

|July 9, 2024

概括

新的纳米酶模仿自然酶来对抗败血症. 这些人造酶减少炎症并保护器官,为败血症和相关炎症性疾病提供有前途的生物催化免疫疗法.

科学领域:

生物材料科学生物材料科学
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

败血症是一种危及生命的疾病,涉及系统性炎症和因感染而导致的器官损伤.
自然氧化还原酶对于控制氧化应激和免疫反应至关重要,但具有实际限制.
目前的治疗方法在酶储存,稳定性和成本方面面临挑战.

研究的目的:

开发用于败血症治疗的多功能人工酶.
评估二氧化 (CeO2) 和金/二氧化 (Au/CeO2) 纳米酶的治疗潜力.
调查它们抑制炎症和调节败血症免疫反应的能力.

主要方法:

合成CeO2和Au/CeO2纳米酶,具有多种类似酶的活动.
对纳米酶模仿活动的评估:超氧化物脱酶,触酶,谷氨过氧化酶,过氧化酶和氧化酶.
在体内评估纳米酶在败血症模型中的疗效,测量反应性氧物种,细胞因子和器官保护.

主要成果:

CeO2和Au/CeO2纳米酶表现出五种不同的类似酶的活动.
纳米酶显著减少了活性氧物种和促炎性细胞因子.
观察到有效的多器官保护和免疫平衡的恢复.

结论:

多功能CeO2和Au/CeO2纳米酶为败血症治疗提供了一种新的生物催化方法.
这些纳米酶提供了一种双重保护策略,防止败血症引起的炎症和器官功能障碍.
这些发现支持开发用于败血症和炎症性疾病的生物催化免疫疗法.

关键词:

氧化氧化物是什么?黄金添加的氧化氧化.免疫反应的免疫反应.这是一种炎症炎症炎症炎症.纳米酶纳米酶是一种纳米酶.这是一种血症.

更多相关视频

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

相关概念视频

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Enzyme-Linked Immunosorbent Assay

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or...