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Updated: Jun 21, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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在Birt-Hogg-Dubé综合征中通过转录和蛋白质组分析来表征FLCN的瘤抑制活性

Andrew Tee1, Rachel-Ann Jones1, Elaine A Dunlop1

  • 1Cardiff University.

Research square
|July 9, 2024
PubMed
概括

在Birt-Hogg-Dubé综合征患者中,毛囊素 (FLCN) 的损失通过损害细胞周期控制和DNA损伤反应增加了癌风险. 这导致不受控制的细胞增殖和瘤形成.

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