Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Indirect Motor Pathways01:22

Indirect Motor Pathways

1.5K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.5K
Neural Regulation01:37

Neural Regulation

39.3K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.

Nature communications·2026
Same author

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation.

CNS neuroscience & therapeutics·2026
Same author

Protein Disulfide Isomerase Disassembles TDP-43/G3BP1 Condensates and Antagonizes TDP-43 Pathological Aggregates.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

NAD<sup>+</sup>‒circadian rhythm coupling in dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.

Signal transduction and targeted therapy·2026
Same author

Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms.

Neuroscience bulletin·2026

相关实验视频

Updated: Jun 21, 2025

Subcellular Patch-clamp Recordings from the Somatodendritic Domain of Nigral Dopamine Neurons
09:17

Subcellular Patch-clamp Recordings from the Somatodendritic Domain of Nigral Dopamine Neurons

Published on: November 2, 2016

14.9K

补丁和矩阵条性黑色神经元不同调节运动运动.

Huaibin Cai1, Jie Dong1, Lupeng Wang1

  • 1National Institutes of Health.

Research square
|July 9, 2024
PubMed
概括
此摘要是机器生成的。

补丁和矩阵条纹黑色神经元对运动有相反的影响. 补丁神经元通过抑制多巴胺能神经元来抑制运动,而矩阵神经元则促进运动.

关键词:
在GABA-B受体 (Gabbr1) 中.克里门1是一个克里门.阿尔德海德脱酶1a1 (ALDH1A1) 是一种多巴胺是多巴胺的一种.背上的条纹体机车运动 机车运动矩阵和补丁隔间的矩阵和补丁.尼格罗斯特里亚塔尔多巴胺基神经元的神经元有刺的投影神经元神经元.状体是什么? 状体是什么黑色物质 (substance nigra) 是一个黑色物质.

更多相关视频

Studying the Neural Basis of Adaptive Locomotor Behavior in Insects
10:19

Studying the Neural Basis of Adaptive Locomotor Behavior in Insects

Published on: April 13, 2011

12.8K
Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

8.8K

相关实验视频

Last Updated: Jun 21, 2025

Subcellular Patch-clamp Recordings from the Somatodendritic Domain of Nigral Dopamine Neurons
09:17

Subcellular Patch-clamp Recordings from the Somatodendritic Domain of Nigral Dopamine Neurons

Published on: November 2, 2016

14.9K
Studying the Neural Basis of Adaptive Locomotor Behavior in Insects
10:19

Studying the Neural Basis of Adaptive Locomotor Behavior in Insects

Published on: April 13, 2011

12.8K
Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

8.8K

科学领域:

  • 神经科学是一个神经科学.
  • 发动机控制器的控制器
  • 状腺功能 状腺功能

背景情况:

  • 已知状神经元会影响运动.
  • 它们在背上条纹体的补丁和矩阵隔间中的特定作用尚不清楚.

研究的目的:

  • 为了研究补丁和矩阵条纹黑色神经元对运动的独特贡献.
  • 阐明潜在的神经机制,包括多巴胺基通路.

主要方法:

  • 利用克林格尔含有蛋白标记眼睛和鼻子的分子标记物 (Kremen1) 和卡尔比丁 (Calb1) 来识别神经元群体.
  • 在小鼠模型中使用光遗传学和纤维光度学.
  • 研究了GABA-B受体Gabbr1在脱酶1A1阳性 (ALDH1A1+) 多巴氨基神经元中的作用.

主要成果:

  • 补丁和矩阵条纹黑色神经元对运动产生相反的影响.
  • 补丁神经元的激活抑制了运动,并抑制了多巴胺的释放.
  • 矩阵神经元的激活促进了运动,并最初增加了多巴胺的释放.
  • 在ALDH1A1+多巴氨基神经元中删除Gabbr1消除了补丁神经元激活的运动抑制作用.

结论:

  • 贴片状神经元通过抑制ALDH1A1+状神经元的多巴胺作用神经元来抑制运动.
  • 矩阵条性黑色神经元促进运动.
  • 这项研究揭示了控制背脊条体内运动的隔间特异性机制.