患有地幔细胞淋巴瘤的患者的感染
Kossi D Abalo1,2, Sara Ekberg1,2, Therese M L Andersson3
1Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University Uppsala Sweden.
HemaSphere
|July 9, 2024
概括
地膜细胞淋巴瘤 (MCL) 幸存者面临两倍的感染风险,感染在诊断前后显著增加. 这凸显了在MCL患者护理中需要更好的感染管理策略.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 改善了地幔细胞淋巴瘤 (MCL) 的治疗方法,使得幸存者数量增加.
- 经历了MCL的幸存者表现出对感染的易感性.
- 了解MCL诊断和治疗的感染发病率至关重要.
研究的目的:
- 评估地幔细胞淋巴瘤 (MCL) 患者感染的发生率.
- 根据临床特征和治疗史分析感染率.
- 将MCL患者的感染风险与匹配的对照组进行比较.
主要方法:
- 使用瑞典国家患者和处方药登记册进行的回顾性队列研究.
- 包括1559名在2007-2019年期间被诊断出MCL患者和15571名匹配的比较者.
- 从诊断/匹配日期到2020年6月30日的随访,识别感染和抗感染药物处置.
主要成果:
- 与对照组相比,MCL患者的感染率 (RRadj=2.14) 增加了两倍.
- 感染率在诊断前4年增加,在诊断后的第一年增加了四倍,并在8年内保持高位.
- 常见的感染包括流感,肺炎,细菌感染,尿道感染和上呼吸道感染;69%的患者在第一年至少有一次感染.
结论:
- 薄膜细胞淋巴瘤 (MCL) 诊断与感染风险的大幅且长期增加有关.
- 感染是MCL幸存者的一个重要问题,需要仔细监测和管理.
- 需要进一步的研究来制定降低MCL患者传染病负担的策略.
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