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Nuclear relaxation restores the equilibrium population imbalance and can occur via spin–lattice or spin–spin mechanisms, which are first-order exponential decay processes.
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代谢物T2的放松时间在一个大型多地点队列中在成年人一生中减少.

Kathleen E Hupfeld1,2, Saipavitra Murali-Manohar1,2, Helge J Zöllner1,2

  • 1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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概括

衰老显著改变了代谢物T2放松时间,影响了磁共振光谱 (MRS) 量化. 这项研究提供了特定年龄的T2方程,以便在体内更准确地估计代谢物度.

关键词:
T2放松时间时间TE系列的TE系列.健康的衰老健康的衰老磁共振光谱学 (MRS) 是一种技术.代谢产物的代谢产物

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科学领域:

  • 神经成像是一种神经成像.
  • 生物物理学的生物物理.
  • 代谢学 代谢学 代谢学

背景情况:

  • 精确的体内磁共振光谱 (MRS) 取决于精确的放松校正.
  • 标准的MRS量化通常假设恒定的放松值,忽略了代谢物T2.2与年龄相关的变化.
  • 以前的研究表明,关键代谢物的T2随着衰老而变化.

研究的目的:

  • 在一个大型的多站点队列中,全面调查T2放松时间和年龄之间的相关性.
  • 为了确定年龄相关的T2变化是否会影响体内代谢物量化.
  • 为提高MRS准确性提供特定年龄的T2值.

主要方法:

  • 在五个年龄十年 (18-60岁以上) 招募了101名参与者.
  • 从白质 (CSO) 和灰质 (PCC) 区域获取了8个回声时间 (TE) 的PRESS数据.
  • 使用Osprey的量化代谢物振幅和通过拟合指数衰变曲线估计的T2.

主要成果:

  • 年龄较大与tNAA,tCr,tCho,Glx和CSO和PCC组织水的T2较短相关 (p<0.05).
  • 在控制皮质缩后,这些关联仍然存在.
  • 对于mI的T2值在成年人寿命中没有差异;对于几个代谢物,观察到T2的区域差异.

结论:

  • 代谢物T2值随着年龄的增长而发生显著变化,因此需要对MRS进行特定年龄的纠正.
  • 该研究提供了估计特定年龄T2值的方程,提高了MRS量化准确性.
  • 未来的3T MRS研究应该纳入这些年龄依赖的T2值,而不是默认常量.