孕期CBD在成年时塑造了岛屿皮层.
bioRxiv : the preprint server for biology
|July 9, 2024
概括
产前接触大麻 (CBD) 会改变小鼠后代的大脑发育. 这种干扰会影响岛屿皮层 (IC),影响情绪处理,并可能导致行为问题.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在怀孕期间使用大麻素 (CBD) 是常见的症状缓解.
- 关于CBD对胎儿发育和后代行为的长期影响的数据有限.
- CBD穿过胎盘,可能会影响胎儿的神经发育.
研究的目的:
- 研究产前CBD暴露对后代发育中的岛内皮层 (IC) 的影响.
- 检查IC神经元功能的性别特异性和区域特异性改变.
- 了解子宫内CBD暴露如何影响情绪处理途径.
主要方法:
- 在怀孕期间 (胚胎5-18天),小鼠接触到低剂量的CBD.
- 在成年后代中分析了岛内皮层神经元的电生理学特性和突触强度.
- 在CBD暴露和对照组之间进行了比较,考虑了性别和IC领土 (前方与后方).
主要成果:
- 产前CBD暴露诱导了IC神经元性质的性别特异和区域特异变化.
- 观察到膜性质,内在兴奋能力和刺激/抑制平衡的变化.
- 暴露于CBD导致前后IC区域之间的功能区分丧失.
结论:
- 在子宫内暴露于CBD会破坏岛内皮层的正常发育.
- 这些干扰可能会对后代的情绪调节和行为产生长期影响.
- 这些发现突出了产前CBD使用对神经发育的潜在风险.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.6K
05:13Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
183
相关概念视频
Anatomy of the Intestines
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Cleavage and Blastulation
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Growth of Cartilage and Bone Tissue
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Zygotic Development And Stem Cell Formation
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Embryonic Connective Tissues
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Bone Formation by Intramembranous Ossification
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
