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Updated: Jun 21, 2025

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

孕期CBD在成年时塑造了岛屿皮层.

Daniela Iezzi, Alba Cáceres-Rodríguez, Jessica Pereira Silva

bioRxiv : the preprint server for biology

|July 9, 2024

概括

产前接触大麻 (CBD) 会改变小鼠后代的大脑发育. 这种干扰会影响岛屿皮层 (IC),影响情绪处理,并可能导致行为问题.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
药理学药理学是指药理学的学科.

背景情况:

在怀孕期间使用大麻素 (CBD) 是常见的症状缓解.
关于CBD对胎儿发育和后代行为的长期影响的数据有限.
CBD穿过胎盘,可能会影响胎儿的神经发育.

研究的目的:

研究产前CBD暴露对后代发育中的岛内皮层 (IC) 的影响.
检查IC神经元功能的性别特异性和区域特异性改变.
了解子宫内CBD暴露如何影响情绪处理途径.

主要方法:

在怀孕期间 (胚胎5-18天),小鼠接触到低剂量的CBD.
在成年后代中分析了岛内皮层神经元的电生理学特性和突触强度.
在CBD暴露和对照组之间进行了比较,考虑了性别和IC领土 (前方与后方).

主要成果:

产前CBD暴露诱导了IC神经元性质的性别特异和区域特异变化.
观察到膜性质,内在兴奋能力和刺激/抑制平衡的变化.
暴露于CBD导致前后IC区域之间的功能区分丧失.

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结论:

在子宫内暴露于CBD会破坏岛内皮层的正常发育.
这些干扰可能会对后代的情绪调节和行为产生长期影响.
这些发现突出了产前CBD使用对神经发育的潜在风险.