通过mTORC2和来协调调节脏葡萄糖再吸收和葡萄糖生成
bioRxiv : the preprint server for biology
|July 9, 2024
概括
脏是一个脏.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢调节 代谢调节 代谢调节 代谢调节
- 分子生物学分子生物学
背景情况:
- 脏靠近管管重新吸收葡萄糖并进行葡萄糖生成 (GNG).
- 胰岛素调节近道管中的葡萄糖运输和GNG,但机制尚不清楚.
- mTORC2复合体对于细胞生长,新陈代谢和恒温至关重要.
研究的目的:
- 研究mTORC2在调节脏葡萄糖再吸收和GNG中的作用.
- 为了阐明参与这些功能中的信号通路.
主要方法:
- 产生的管体特异性Rictor淘汰赛 (TRKO) 没有mTORC2.2的小鼠.
- 在不同的饮食条件下评估了代谢参数,葡萄糖平衡和功能.
- 分析脏和肝脏组织的葡萄糖生成酶,mTORC2点和葡萄糖运输体.
主要成果:
- 由于SGLT2/SGLT1.1减少,TRKO小鼠表现出糖尿和脏葡萄糖再吸收受损.
- 这些小鼠表现出性胰岛素耐药性的迹象,包括高的禁食胰岛素和受损的酸盐耐受性.
- 在TRKO小鼠中,高摄入量预防了糖尿和过量的GNG,独立于mTORC2信号.
结论:
- 管 mTORC2 对于协调-葡萄糖携带和 GNG 是必不可少的.
- 饮食中的通过独立于胰岛素和mTORC2.2.的机制影响脏的葡萄糖处理和生产.
- 这些发现为糖尿病管理提供了新的治疗点.
更多相关视频
10:37Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
131
08:01Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
5.8K
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
cAMP-dependent Protein Kinase Pathways
6.3K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.3K
Introduction to Urinary System
2.4K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.4K
Glomerular Filtration Rate and its Regulation
2.5K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.5K
Regulation of Metabolism
9.3K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.3K
