在体内皮层折叠开始时,子板和皮质板微观结构的动态变化
Siân Wilson1,2,3,4, Daan Christiaens5, Hyukjin Yun2,3,4
1Research Department of Early Life Imaging, Kings College London, London, United Kingdom.
bioRxiv : the preprint server for biology
|July 9, 2024
概括
大脑折叠模式,或皮层旋转,与胎儿大脑区的微观结构变化有关. 这些子板和皮质板的变化先于沟的形成,这表明它们在大脑发育中起着机械作用.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 皮层转化或大脑折叠对人类大脑发育至关重要,主要发生在第二到第三个三个月.
- 驱动皮层折叠的潜在生物机制在很大程度上是未知的.
- 之前的工作模拟了子宫扩散信号,以追踪胎儿大脑区内的微结构成熟.
研究的目的:
- 为了研究过渡性胎儿区的微观结构成熟与皮层旋转之间的相关性.
- 探索在皮质板 (CP) 和子板 (SP) 中的深度和组织异质性之间的关系.
主要方法:
- 在子宫中利用了来自"发展人类连接体项目" (dHCP) 的高角度分辨率多扩散权重成像 (HARDI) 数据.
- 应用扩散信号建模来量化CP和SP中的微结构成熟和组织异质性.
- 与岩深度相关的扩散指标以及旋转和岩区域之间的区域差异.
主要成果:
- 在SP和CP的扩散信号的异型组织组成部分的下降被观察到,这在状坑的形成之前就发生了.
- 证据表明,未来的旋转和状区域之间的细胞结构差异是在第二个三个月后期发现的.
- 过渡性胎儿区的微观结构的区域变化在皮层折叠开始之前发生.
结论:
- 亚板和皮质板的微结构成熟在皮质折叠的出现中起着机械作用.
- 胎儿大脑微观结构的区域差异先于并可能驱动皮质化的模式.
- 这项研究提供了对人类大脑折叠背后的发育过程的见解.
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