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Updated: Jul 14, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

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在子选中,SHPRH被确定为一种新型核细胞酸补丁交互器

Allison M James, Ernst W Schmid, Johannes C Walter

    bioRxiv : the preprint server for biology
    |July 9, 2024
    PubMed
    概括

    研究人员使用AlphaFold-Multimer选了7000种人类蛋白质,以找到新的核细胞酸补丁结合剂. 他们从结构上描述了SHPRH,揭示了核细胞体上一种新的结合相互作用和ATPase参与点.

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    Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b10:20

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    Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors08:45

    Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

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    相关概念视频

    Patch Clamp01:18

    Patch Clamp

    Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
    In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...