通过隔离的皮质杏仁体电路控制先天的嗅觉价值
James R Howe1,2,3,4, Chung-Lung Chan1,4, Donghyung Lee1
1Department of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
bioRxiv : the preprint server for biology
|July 9, 2024
概括
后侧皮质杏仁体 (plCoA) 使用不同的神经元群体来控制对气味的天生的吸引力和厌恶. 这个大脑区域的大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统研究研究 嗅觉系统研究
- 行为神经科学 行为神经科学
背景情况:
- 天生的行为是对进化相关刺激的刻板印象反应.
- 后侧皮质杏仁体 (plCoA) 调解着对气味的天生的吸引力和厌恶.
- 如何plCoA产生相反的动机价值行为在很大程度上是未知的.
研究的目的:
- 确定plCoA的电路特征,这些特征是对气味的天生的吸引力和厌恶的基础.
- 描述plCoA.的生理学,基因表达和投影.
- 了解嗅觉系统是如何产生固定的吸引力和回避行为.
主要方法:
- 气味唤起的反应分析.
- 对plCoA域进行光遗传刺激.
- 单细胞和空间RNA测序.
- 神经元群体的化学遗传抑制.
- 神经元投射的追踪. 神经元投射的追踪.
主要成果:
- 观察到气味标识的稀疏编码,而不是价值.
- 前部plCoA的光遗传刺激引起了吸引力,而后部刺激引起了回避.
- 确定了细胞类型的前后梯度:前部神经元表达VGluT2,后部神经元表达VGluT1.
- 这些细胞类型的激活重现了食欲和厌恶行为.
- 截然不同的投射模式:前部神经元投射到中部杏仁体,后部神经元投射到核.
结论:
- 在plCoA展出地形组织控制天生的吸引力和回避.
- 在plCoA中,通过基因表达和投影定义的独特的神经元群体,介导着对应特异性行为.
- 一个新的杏仁体电路图案表明,人口层面对价值的编码,通过不同的目标进行路由.
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