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Updated: Jun 21, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Published on: January 16, 2016

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通过在扩散模型中约束催化口袋来设计细胞染色体P450酶.

Qian Wang1,2,3, Xiaonan Liu1,2,3, Hejian Zhang1,3,4

  • 1Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

Research (Washington, D.C.)
|July 9, 2024
PubMed
概括

研究人员发现了在细胞P450酶中推动功能创新的关键残留物. 一个新的模型解释了这些生物催化剂如何演变,使得人工P450s具有增强的催化能力的创造成为可能.

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