电聚苏胺基支架含有不同的盐作为潜在的伤口料材料
Veronika Pálos1, Krisztina S Nagy1, Rita Pázmány1
1Laboratory of Nanochemistry, Institute of Biophysics and Radiation Biology, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary.
Beilstein journal of nanotechnology
|July 9, 2024
概括
这项研究开发了可生物降解的聚合物支架,使用聚苏胺 (PSI) 和抗菌盐,如酸或酸,用于先进的伤口包裹. 新的支架显示出有希望的机械性能,抗菌活性和低细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 像银离子这样的常规抗菌剂会给环境带来风险和潜在的免疫反应.
- 需要新的,可生物降解的伤口包裹材料,具有有效的抗菌和组织再生特性.
研究的目的:
- 使用聚苏胺 (PSI) 和抗菌盐 (酸,酸) 创建和描述两组分生物降解聚合物支架.
- 评估这些脚手架的物理化学,机械和生物特性,以潜在的生物医学伤口包裹应用.
主要方法:
- 电用于制造PSI的纳米纤维支架,并加入抗菌盐.
- 扫描电子显微镜 (SEM),里埃变换红外光谱 (FTIR) 和能量分散式X射线光谱 (EDX) 用于结构和组成分析.
- 进行了机械测试,溶解研究,抗菌检测和细胞毒性测试,以评估脚手架的性能.
主要成果:
- 脚手架制造导致纤维直径低于500纳米,盐影响机械性能 (负载能力,延长).
- 酸在8小时内完全溶解,而酸显示50%的溶解.
- 大多数支架对相关细菌菌株具有显著的抗菌活性,对健康和瘤细胞无细胞毒性 (除了酸).
结论:
- 具有酸或酸的可生物降解的基于PSI的支架是先进伤口包裹系统的可行候选者.
- 开发的支架显示了可调节的特性,有效的抗菌作用和良好的生物相容性,为传统治疗提供了替代方案.
相关概念视频
Gustation
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
Glycosaminoglycans
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Potentiometry: Membrane Electrodes
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
The Physiology of Taste
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...


