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用于双螺丝挤压的螺丝元件的实验和数值表征
Vanessa Düphans1, Vincent Kimmel1, Lukas Messing1
1Department of Biochemical and Chemical Engineering, Laboratory of Solids Process Engineering, TU Dortmund University, Dortmund, Germany.
Pharmaceutical development and technology
|July 9, 2024
概括
了解热挤出 (HME) 工艺对于制药设计质量至关重要. 这项研究开发了一个实验和计算流体动力学 (CFD) 框架来分析双螺杆挤出机输送元件,揭示了对其性能的见解.
科学领域:
- 制药工程 制药工程
- 工艺工程是过程工程.
- 材料科学 材料科学 材料科学
背景情况:
- 热挤出 (HME) 使用协同旋转的双螺杆挤出机在制药中至关重要.
- 在HME中,全面的过程理解对于设计质量 (QbD) 是必不可少的.
- 输送元件的性能是HME的关键过程参数.
研究的目的:
- 开发一个综合的实验和数值框架来分析双螺杆挤出机输送元件.
- 为了比较不同螺丝元件设计及其变化的性能.
- 提高对HME中关键过程参数的理解.
主要方法:
- 设计和建造一台高精度测试装置,用于测量体积流量,压力和扭矩.
- 3D计算流体动力学 (CFD) 模拟使用带有明显螺丝运动的静止模型.
- 将实验数据与Pawlowski模型相匹配,以确定压力和功率特征参数.
- 使用CFD对原生和磨损的螺丝元件进行系统调查.
主要成果:
- 实验数据显示与Pawlowski模型有很好的一致性.
- 差价合约模拟提供了与文献一致的结果,并且在计算上是高效的.
- 调查显示,螺丝元件的变化影响了运输能力和压力增加.
- 与原生元素相比,磨损的螺丝元件显示压力增加的减少和运输能力的增加.
结论:
- 开发的实验和CFD框架有效地评估了协同旋转的双螺丝元件的性能.
- 差价合约模拟为HME过程分析提供了一种灵活且计算成本低廉的方法.
- 了解螺杆元件性能是优化医药应用HME流程的关键.
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