艾滋病毒控制者的功能和结构性神经质神经系统障碍. 预期的队列研究
Susana Ruiz-Bilbao1,2, Sebastian Videla2,3, Ester Pascual1
1Department of Ophthalmology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
HIV medicine
|July 9, 2024
概括
神经视网膜疾病 (NRD) 在艾滋病毒感染者 (PLWH) 中非常普遍,包括未接受抗逆转录病毒治疗 (ART) 的艾滋病毒控制者. 这些发现表明NRD可能表明PLWH的眼睛衰老.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 神经视网膜疾病 (NRD) 是艾滋病毒感染者 (PLWH) 的一个问题.
- 了解不同艾滋病毒管理组的NRD流行和发病率至关重要.
研究的目的:
- 估计艾滋病毒控制者中NRD的流行率和累积发病率.
- 为了比较艾滋病毒控制者,抗逆转录病毒疗法 (ART) 患者和非艾滋病毒控制者的NRD.
主要方法:
- 前性,单中心队列研究.
- 包括艾滋病毒控制者 (精英和长期非进展者) 离开ART,艾滋病毒感染者接受ART,以及匹配的非艾滋病毒队列.
- 评估功能和结构眼科参数,以及生活质量.
主要成果:
- 与非艾滋病毒对照组 (56.3%) 相比,艾滋病毒控制组 (88.2%) 和艾滋病毒治疗组 (90.9%) 的高基线NRD患病率.
- 在两组艾滋病毒感染者中,NRD的累积发病率在3年内增加.
- 对比度敏感性和结构参数在PLWH中受到影响最大; 艾滋病毒控制者的生活质量受到影响.
结论:
- 艾滋病毒感染者 (PLWH),包括艾滋病毒控制者,比非艾滋病毒感染者更容易患上NRD.
- 在PLWH中,NRD可以作为眼睛衰老的生物标志物.
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