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抗生素浸泡和灌溶液使充气阴茎假体水友表面的抗菌效率提高,与0.05%的赫西丁葡萄糖酸盐相比

Rishabh Simhal¹, Brian H Im¹, Sohan Shah¹

¹Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.

The journal of sexual medicine

|July 9, 2024

概括

范科米辛和珍塔米辛 (VG) 抗生素在防止细菌粘附在阴茎假肢 (PP) 表面方面比素酸盐 (CHG) 更有效. 作为浸泡和灌溶液的VG在体外显著降低了细菌粘附.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
生物材料科学生物材料科学
传染性疾病传染性疾病

背景情况:

阴茎假体 (PP) 手术越来越多地使用水友表面.
赫西丁葡萄酸盐 (CHG) (0.05%) 是一种用于PP手术的拟议抗菌剂.
与传统抗生素相比,CHG的疗效需要评估.

研究的目的:

为了比较0.05%的CHG的体外抗菌疗效与万科米辛和 جنت米辛 (VG) 抗生素.
评估VG和CHG作为水友性PP表面的浸泡和灌解决方案.
为了评估对甲素敏感的金黄色葡萄球菌对PP表面的粘附的减少.

主要方法:

水友性PP盘被化为对甲基西林敏感的黄金色杆菌.
使用正常盐水 (NS),0.05%CHG或VG作为浸泡和/或灌溶液测试了抗菌疗效.
通过殖民地数量量化细菌粘附,盘扩散测试测量了抑制区域.

主要成果:

入VG显著降低了细菌粘附率超过0.05%的CHG (P < .01).
CHG或NS灌未能防止浸泡后的细菌生长.
单独或用CHG/NS浸泡进行VG灌,有效减少了细菌粘附,并证明了抗菌活性.

结论:

相比于0.05%的CHG和NS对水友性PP表面,香草素和甘他素 (VG) 的抗菌疗效优于0.05%.
作为预防性浸泡和手术内灌溶液,VG既有效.
这项研究强调了VG在减少PP手术过程中手术部位感染的潜力.

关键词:

在0.05%的素基酸盐中.抗生素抗生素是一种抗生素.水友的表面水友的表面感染的感染感染.阴茎假体是一种阴茎假体.

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