从精神分裂症不同阶段的全血细胞计中获得的炎症标志物的评估
Merve Bilgin Koçak1, Neşe Öztürk Atkaya2, Muhammet Ali Oruç3
1Department of Psychiatry, Samsun Mental Health and Diseases Hospital, İlkadım, Samsun, Turkey.
Current medical research and opinion
|July 9, 2024
概括
系统性炎症标志物如中性粒细胞/淋巴细胞比率 (NLR) 和系统性炎症反应指数 (SIRI) 在精神分裂症恶化期间升高,这表明它们可能表明疾病状态. 单细胞/淋巴细胞比 (MLR) 可能是一个特征标记.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 系统性炎症生物标志物,包括中性粒细胞/淋巴细胞比率 (NLR),单细胞/淋巴细胞比率 (MLR),血小板/淋巴细胞比率 (PLR),系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI),已在精神分裂症中进行了研究.
- 系统性炎症反应指数 (SIRI) 是一种新的炎症标志物,在不同精神分裂症阶段之前尚未研究过.
研究的目的:
- 为了比较精神分裂症患者在精神病恶化和缓解期间的NLR,MLR,PLR,SII和SIRI值.
- 将这些炎症标志物值与健康对照组的值进行比较.
主要方法:
- 该研究包括86名因精神病复发而住院的精神分裂症患者,以及在缓解期间同样的患者.
- 还分析了86名年龄和性别匹配的健康对照对象.
- 在精神病恶化 (PE),缓解 (R) 和健康对照 (HC) 组之间比较了炎症标志物值.
主要成果:
- 与HC组相比,精神分裂症-PE组的NLR,MLR,PLR,SII和SIRI显著高于HC组.
- 与精神分裂症R组相比,精神分裂症-PE组的NLR,MLR,SII和SIRI显著更高.
- 与HC组相比,MLR在精神分裂症-R组显著更高.
结论:
- NLR,SII和SIRI可以作为精神分裂症的状态生物标志物,反映当前的疾病活动.
- MLR可能是精神分裂症的特征标记,可能表明一种倾向或持久的特征.
- 这些发现强调了系统性炎症在精神分裂症不同阶段的作用.
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