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Updated: Jun 21, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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定位蛋白质降解速度的定量测量

Thomas L Lynch1, Violeta L Marin2, Ryan A McClure2

  • 1Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States.

ACS chemical biology
|July 9, 2024
PubMed
概括

向蛋白质降解 (TPD) 利用细胞的机械来降解蛋白质. 这项研究量化了TPD分子的催化速率,揭示了它是降解剂有效性的关键预测因素.

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Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
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