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对任务和无任务BOLD fMRI的可变性和复杂性测量的可靠性
Maren H Wehrheim1,2,3, Joshua Faskowitz4, Anna-Lena Schubert5
1Department of Psychology, Goethe University Frankfurt, Frankfurt, Germany.
Human brain mapping
|July 9, 2024
概括
大脑信号变化和复杂度的测量是可靠的研究个体差异. 全球功能连接的时间变化为量化大脑动态提供了一个强大的新方法.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 脑部成像 脑部成像
背景情况:
- 大脑活动表现出连续的时间波动,即使在受控状态下.
- 了解这些变异对于发育,个体差异和临床研究至关重要.
- 大脑信号可变性和复杂性测量的心理测量可靠性尚未得到充分证实.
研究的目的:
- 用休息状态和基于任务的fMRI数据评估大脑信号可变性和复杂性指标的可靠性.
- 评估这些措施是否适合个人差异和纵向研究.
- 调查区域大小和扫描长度对可靠性的影响.
主要方法:
- 检查了BOLD fMRI数据 (静止状态和基于任务) 的分半和测试-重新测试可靠性.
- 计算的时间变化 (例如标准偏差) 和复杂性 (例如) 的测量.
- 分析了时间解决的功能连接,并评估了不同大脑区域和分片化策略的可靠性.
主要成果:
- 从激活时间序列的时间变化度的分半可靠性良好至优异.
- 在休息条件下测试时间变化度的中等测试-重试可靠性.
- 从激活时间序列的复杂度指标中等到良好的可靠性;从功能连接的复杂度指标的可靠性差.
- 全球测量和较大的皮质下区域显示出比特定区域或小区域测量更高的可靠性.
- 可靠性仅受到扫描长度的轻微影响.
结论:
- BOLD激活时间序列的可变性和复杂性是个体差异研究的可靠指标.
- 全球功能连接的时间变化是量化大脑动态的新且强大的方法.
- 这些发现支持在神经成像研究中使用BOLD信号的变化性和复杂性.
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