怀孕期间的空气污染暴露和儿童的肺功能:LUIS研究
Jakob Usemann1,2,3, Rebeca Mozun4,5, Claudia E Kuehni3,4
1Department of Respiratory Medicine, University Children's Hospital Zurich, Zurich, Switzerland.
Pediatric pulmonology
|July 9, 2024
概括
产前暴露于中度空气污染,特别是细颗粒物 (PM2.5),与儿童的肺功能下降有关. 这些影响在年幼的儿童中最为明显,突出显示了子宫内发育的脆弱性.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
背景情况:
- 众所周知,高空气污染会损害儿童的肺功能.
- 关于早期适度空气污染暴露及其对肺功能影响的数据有限.
研究的目的:
- 调查怀孕,婴儿和学龄前期中等程度的空气污染暴露与学龄期的肺功能之间的联系.
- 评估细颗粒物 (PM2.5) 和二氧化 (NO2) 对瑞士人口肺功能的影响.
主要方法:
- 利用精细尺度的时空模型进行PM2.5和NO2暴露估计.
- 将暴露数据与2182名儿童 (6-17岁) 的住所病史联系起来.
- 使用调整为混因子的线性回归模型来评估与不同时间窗口中的暴露相关的肺功能 (FEV1,FVC).
主要成果:
- 产前PM2.5暴露与学龄肺功能 (FEV1和FVC) 的降低有关.
- 在12岁时,产前PM2.5增加10μg·m−3与FEV1下降55毫升和FVC下降62毫升相关.
- 产后的PM2.5和任何NO2暴露与肺功能没有显著的关联.
结论:
- 在子宫中,即使是适度水平的PM2.5暴露也会对肺部发育产生重大影响.
- 产前暴露是空气污染对肺功能影响最敏感的时期.
- 观察到的关联在年幼的儿童中更强烈,表明年龄相关的易感性.
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