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对从事职业癌症监测的内部和外部参考人群的比较,从多样化的劳动力中抽取的队列
Louis Everest1, Shirui Tan1, Tanya Navaneelan1
1Occupational Cancer Research Centre, Ontario Health, Toronto, Ontario, Canada.
American journal of industrial medicine
|July 9, 2024
概括
在职业癌症风险研究中,选择合适的对照组至关重要. 使用一般人口比率,而不是内部群体,影响研究结果,并可能改变特定工人群体对癌症风险的看法.
科学领域:
- 职业流行病学 职业流行病学
- 癌症监测 癌症监测 癌症监测
- 公共卫生研究 公共卫生研究
背景情况:
- 职业病监测系统 (ODSS) 分析传统上使用内部参考组.
- 在工人队伍中评估癌症风险需要仔细选择对照人群.
研究的目的:
- 用一般人口率来估计职业队列中的癌症风险.
- 评估对照群体对监测结果的影响.
- 探索内部和外部参考组之间的癌症风险估计的不一致性.
主要方法:
- 分析了一组230万安大略省工人接受索赔 (1983-2018) 的队列.
- 对所有队列成员的癌症诊断都进行了跟踪.
- 使用内部 (ODSS队列) 和外部 (一般人口) 参考组计算了标准化发病率 (SIR).
主要成果:
- 基于一般人群的SIR通常与使用内部参考组的SIR相似或略低.
- 在特定职业的尿道,前列腺和结直肠癌中观察到不一致的SIR方向 (内部增加,外部减少).
- 参考组的选择影响了观察到的癌症风险关联.
结论:
- 参考组的选择对职业监测中癌症风险的解释产生了重大影响.
- 混和健康工人招聘偏见可能因所研究的职业和癌症部位而异.
- 这些发现凸显了在职业病监测中需要仔细考虑对照群体的必要性.
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