持续的先天性干扰素是第三级淋巴体结构的重要诱导剂
Anna Laura Calvanese1, Virginia Cecconi1, Severin Stäheli1
1Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
European journal of immunology
|July 9, 2024
概括
I型干扰素 (IFN-I) 对于肺部三级淋巴体结构 (TLS) 的发展至关重要. 这涉及到吸引B细胞和T细胞的IFN-I信号通路,导致功能性生殖中心.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 模仿二级淋巴体器官,并在炎症和癌症期间在非淋巴体组织中形成.
- 驱动TLS发展的特定细胞类型和信号通路在很大程度上是未知的.
- 了解TLS形成对于开发用于炎症性疾病和癌症的新治疗策略至关重要.
研究的目的:
- 调查早期的细胞和分子事件驱动TLS在肺部的发展.
- 识别TLS形成所必需的关键信号分子和细胞类型.
- 阐明I型干扰素 (IFN-I) 影响TLS发展的机制.
主要方法:
- 在小鼠模型中,多次鼻入灌注聚 (I:C) 加卵 (Ova).
- 诱导TLS的分析,从聚合物到有生殖中心的有组织结构.
- 研究了FAP+纤维细胞,膜巨细胞,CCL19和I型干扰素 (IFN-I) 在TLS发育中的作用.
主要成果:
- TLS的发育独立于FAP+纤维细胞,膜巨细胞和CCL19.
- TLS的形成严重依赖于I型干扰素 (IFN-I).
- IFN-I启动了两个协同作用的途径:通过LTβR诱导LTα产生CXCL13,以及直接传感T细胞化学因子 (CXCL9,CXCL10,CCL19,CCL21).
结论:
- 持续的I型干扰素 (IFN-I) 生产,以及抗原的存在,对于诱导肺部功能性TLS至关重要.
- IFN-I编排了涉及淋巴细胞和树皮细胞的独特信号级联,以驱动TLS的形成.
- 这些发现为TLS的免疫生物学和潜在的治疗点提供了关键的见解.
更多相关视频
10:00High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
13.4K
07:07Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
5.3K
相关概念视频
Immune Response Against Viral Pathogens
770
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
770
Cells of the Adaptive Immune Response
977
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
977
Cell-mediated Immune Responses
68.0K
Overview
68.0K
T Cell Types and Functions
996
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
996
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Introduction to Innate and Adaptive Immunity
3.9K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
3.9K
