科伦博兰Ubx的功能演变对调节腹部附属体形成的作用
Yan Liang1,2,3, Yun-Xia Luan4,5
1Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China. yl10@sanger.ac.uk.
Development genes and evolution
|July 9, 2024
概括
这项研究揭示了Folsomia candida的Ubx基因在早期发育期间抑制Dll基因的效果较低,这表明它在昆虫和甲类动物之间的附属物形成中发挥了中间作用.
科学领域:
- 进化发育生物学 进化发育生物学
- 关节动物基因组学
- 分子进化分子进化
背景情况:
- 虫,土壤节肢动物,具有类似昆虫的特征和腹部附属物.
- 结膜体Ubx和Abda基因指定了附属体,但未能抑制DLL基因.
- 结膜尾形成的遗传基础以及DLL的Ubx/AbdA调节是未知的.
研究的目的:
- 研究福尔索米亚候选菌中尾形成的遗传基础.
- 分析 Ubx 和 AbdA 在 Dll 转录上的调节机制.
- 了解关节动物中Ubx的功能演变.
主要方法:
- 分析了Folsomia candida的发育转录组.
- 确定了候选附属体形成基因,包括FcUbx.
- 使用电泳运动转移试验和双光酶试验.
主要成果:
- 在胚胎早期发育 (3.5和4.5天) 期间,DLL表达在Ubx上占主导地位.
- 福尔索米亚candida Ubx (FcUbx) 结合和抑制多 Dll 与多 Ubx (DmUbx_Ib) 相似.
- FcUbx对Dll抑制的C端调节类似于甲类动物Artemia franciscana Ubx (AfUbx).
结论:
- 福尔索米亚candida Ubx的功能是昆虫和甲类之间的中间.
- 在F. candida. 早期的形形成阶段,Ubx在抑制Dll方面缺乏.
- 提出了一个由collembolan Ubx对腹部段的特定环境调节模型.
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