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甲与其他阿片类药物治疗耐火性恶性骨痛:试点随机对照研究

Merlina Sulistio^1,2,3, Alexandra Gorelik^4,5, Hoong Jiun Tee^6,7,8

¹Cabrini Health, Melbourne, VIC, 3144, Australia. msulistio@cabrini.com.au.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

|July 9, 2024

概括

甲轮换 (MR) 和其他阿片类药物轮换 (OOR) 是可行的,安全的,可接受的,用于管理耐癌症诱导的骨疼痛 (CIBP). 这两种方法都有效地减少了CIBP患者的疼痛并改善了他们的生活质量.

科学领域:

在瘤学瘤学.
疼痛管理疼痛管理
药理学药理学是指药理学的学科.

背景情况:

耐药性癌症诱导的骨疼痛 (CIBP) 显著损害了患者的功能和生活质量.
仅有有限的证据来指导最佳阿片类药物选择来管理CIBP.
本研究解决了在CIBP管理中需要基于证据的策略的需求.

研究的目的:

评估甲旋转 (MR) 与其他阿片类药物旋转 (OOR) 的可行性,耐受性和潜在疗效,用于耐火性CIBP患者.
为了评估癌症疼痛的阿片类药物轮换后的患者结果.
为未来对CIBP中阿片类药物管理的大规模研究提供初步数据.

主要方法:

一项随机对照试验比较了成年CIBP患者的MR与OOR.
参与者最严重的疼痛强度≥4/10或阿片类毒性等级≥2.2.
在轮换后的14天内进行了标准化评估.

主要成果:

在51名符合条件的参与者中,有29人完成了14天的随访.
无论是MR和OOR组都显示出平均和最严重的疼痛强度以及总疼痛干扰得分的显著降低.
与OOR组相比,MR组的每日口服吗啡相当剂量显著减少. 与阿片类药物相关的不良事件在OOR组较低.

结论:

甲轮换和其他阿片类药物轮换对于耐火性CIBP患者来说是可行的,安全的和可以接受的.
这两种策略都在减少疼痛和改善疼痛干扰方面表现出有效性.
进一步的大规模多中心随机对照试验是有必要的,以证实MR和OOR在这个患者群体中的有效性.

关键词:

骨头疼痛骨头疼痛骨头疼痛甲顿是一种甲.这是一种阿片类药物.疼痛控制控制疼痛的方法耐火性疼痛是一种耐火性疼痛.

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