在癌症患者中治疗COVID-19的口服抗病毒药物
Dorra Guermazi1,2, Panos Arvanitis3, Kendra Vieira3
1Brown University, 69 Brown St. Providence, Providence, RI, 02912, USA. dorra_guermazi@brown.edu.
概括
像Paxlovid和Lagevrio这样的口服抗病毒药物可能会改善COVID-19癌症患者的生存率. 早期使用这些药物的治疗降低了死亡率和氧气需求,在一项针对免疫功能低下个体的小型研究中.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫功能低下的癌症患者面临SARS-CoV-2 (COVID-19) 的严重风险.
- 有限的数据存在于口服抗病毒疗效 (nirmatrelvir/ritonavir,molnupiravir) 在这个高风险组.
- 最近的研究使人们对接种疫苗的人的抗病毒有效性产生了怀疑,即使是那些有风险因素的人.
研究的目的:
- 为了评估nirmatrelvir/ritonavir和molnupiravir的疗效和安全性.
- 评估COVID-19的癌症患者严重疾病和死亡的预防.
主要方法:
- 对457名患有COVID-19的癌症患者进行了回顾性分析.
- 67名接受尼马特里尔维尔/里托纳维尔或莫尔努皮拉维尔治疗的患者与45名未接受治疗的对照进行了比较.
- 从布朗大学附属医院收集的数据.
主要成果:
- 抗病毒治疗与改善的生存率有关.
- 在接受治疗的患者中观察到较低的90天全因和COVID-19相关死亡率 (p<0.05).
- 接受治疗的患者需要较低的氧气峰值 (O2) 支持 (OR 1.52,95% CI 0.92-2.56).
结论:
- 早期的抗病毒疗法可能有利于COVID-19的免疫功能低下的癌症患者.
- 研究样本大小小,需要进一步调查.
- 需要进行更大规模的分层研究来证实这些发现.
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