在老年人中使用可能不合适的药物的高率:一个病例控制研究
András Érszegi1,2, Dezső Csupor1,3, Gabriella Bodó4
1Faculty of Pharmacy, Institute of Clinical Pharmacy, University of Szeged, Szeged, Hungary.
GeroScience
|July 9, 2024
概括
潜在不合适的药物 (PIMs) 增加了老年人的跌倒风险. 这项研究确定了像piracetam和trimetazidine这样的特定PIM作为高风险跌倒剂.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 老年人的跌倒是越来越严重的公共卫生问题,导致严重损伤.
- 多药和营养不良是已知的老年人倒的危险因素.
研究的目的:
- 评估药物之间的关联,特别是那些在欧盟(7) -PIM名单上的药物,以及老年人中跌倒的风险.
- 确定增加或减少跌倒风险的特定药物.
主要方法:
- 进行了一项病例对照研究,涉及患有摔倒的患者和对照组.
- 分析了来自匈牙利886名摔倒患者和1364名对照者的数据.
- 用调整的几率比率 (AOR) 评估了药物数据,包括EU(7)-PIM状态,以评估与跌倒事件的关联.
主要成果:
- 使用≥2个EU(7) -PIM药物与较高的跌倒风险有关 (AOR, 1.38).
- 皮拉 (AOR,1.81) 和三甲 (AOR,1.62) 显示增加了跌倒的风险.
- 长效的二,抗抑郁药,SNRIs和SSRIs也增加了跌倒风险,而多克萨佐辛和Z药物显示风险降低.
结论:
- 特定的药物,包括piracetam和trimetazidine,与老年人跌倒的风险增加有关.
- 这项研究强调了药物审查对于老年人跌倒预防策略的重要性.
- 一些不在欧盟PIM名单上的药物,如蒂亚普里德和格利克拉齐德,也会带来很大的跌倒风险.
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