产前暴露于环境空气污染和脑
Yu Zhang1, Yuhong Hu1, Robert Talarico2,3
1Department of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, Massachusetts.
JAMA network open
|July 9, 2024
概括
产前暴露于细颗粒物 (PM2.5) 空气污染与儿童患脑 (CP) 的风险更高有关. 该协会强调空气质量是这种常见的儿童运动残疾的潜在环境风险因素.
科学领域:
- 环境健康 环境健康
- 儿科神经学 儿科神经学
- 流行病学 流行病学
背景情况:
- 众所周知,空气污染会影响大脑发育,并与神经发育障碍有关.
- 产前空气污染暴露对脑 (CP) 风险的具体影响仍未得到充分研究.
研究的目的:
- 检查怀孕期间居民暴露于环境空气污染和产期出生的儿童中CP的风险之间的关联.
- 识别有助于CP发展的潜在环境风险因素.
主要方法:
- 加拿大安大略省的一项基于人口的队列研究利用了链接的卫生行政数据库.
- 包括2002年至2017年间单独,满期分娩 (≥37周怀孕) 的情况.
- 根据母亲的居住地,评估产前暴露于细颗粒物 (PM2.5),二氧化 (NO2) 和臭氧 (O3) 的情况.
主要成果:
- 在1,587,935名母婴对中,有3,170名 (0.2%) 儿童被诊断患有CP.
- 产前增加的PM2.5暴露 (每次IQR增加) 与CP (1.12;95% CI,1.03-1.21) 的高累积危险比率有关.
- 这种关联在男婴中更为明显. 对于NO2或O3暴露,没有发现显著的关联.
结论:
- 产前暴露于环境PM2.5与子女脑风险增加有关.
- 这一发现表明PM2.5是CP的潜在环境风险因素.
- 需要进一步的研究来阐明这种关联背后的生物学途径.
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