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从2012年到2018年在康涅狄格州长期艾滋病毒暴露前预防持续性和重新启动

Jun Tao^1,2, Mofan Gu³, Omar Galarraga⁴

¹Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Population health management

|July 9, 2024

概括

在美国,艾滋病毒暴露前预防 (PrEP) 的遵守率很低. 许多患者重新启动PrEP,但持续时间很短,可能会增加艾滋病毒风险. 需要采取干预措施来改善PrEP的使用和减少感染.

科学领域:

公共卫生公共卫生
流行病学流行病学
生物医学预防生物医学预防

背景情况:

艾滋病毒暴露前预防 (PrEP) 是预防艾滋病毒感染的关键生物医学干预措施.
始终坚持PrEP是其有效性至关重要的.
关于美国PrEP持久率的数据有限.

研究的目的:

在康涅狄格州填写处方的个人中评估PrEP持久性.
确定与PrEP停用和重新开始相关的因素.
了解在现实世界中使用PrEP的持续时间.

主要方法:

从2012年至2018年使用了康涅狄格州所有付款人索赔数据库 (APCD).
确定了1576名启动了PrEP的患者.
断药被定义为药物补充的30天间隔;使用卡普兰-梅尔曲线和考克斯回归分析了持久性.

主要成果:

初始PrEP持续时间的中位数为3个月 (IQR:1-6个月).
大约67.5%的停止PrEP的患者重新开始使用它,但随后的持续时间也平均为3个月.
女性性别,家长保险和高共同支付与更短的PrEP持续时间有关.

结论:

在康涅狄格州,在开始使用PrEP的患者中,PrEP的持续性显著较低.
虽然许多患者重新启动PrEP,但持续的坚持仍然是一个挑战.
制定有针对性的干预措施对于提高PrEP持续性和减轻艾滋病毒传播风险至关重要.

关键词:

暴露前预防暴露前预防索赔数据索赔数据索赔数据持续性持久性重新启动重新启动

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