长期暴露于抗生素的景观和在人口密的环境中抵抗性大肠杆菌殖民
Eric Ng'eno1,2, Marlon E Cobos2, Samuel Kiplangat1
1Centre for Global Health Research, Kenya Medical Research Institute, Nairobi, Kenya.
PloS one
|July 9, 2024
概括
社区抗生素暴露与耐药大肠杆菌殖民有关. 精细的暴露数据澄清了这些关系,为抗生素管理计划提供了信息.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
背景情况:
- 接触抗生素与抗生素耐药细菌的殖民化有关.
- 由于传输和分配模式,社区层面的关系是复杂的.
- 需要精确的暴露估计来理解这些关联.
研究的目的:
- 在社区层面调查抗生素暴露与耐药性大肠杆菌殖民之间的关联.
- 开发精细的地方级抗生素暴露估计.
- 探索环境因素对抗生素耐药性的影响.
主要方法:
- 利用了来自地理参考家庭的23种抗生素类型的处方数据 (2010-2015年).
- 生成的抗生素暴露估计 (DDD每1000个居民观察日).
- 分析了使用统计模型从便培养物中获得的大肠杆菌殖民数据 (安皮西林,塞夫塔齐迪姆,三甲-硫甲抗性).
主要成果:
- 三甲-硫甲醇和阿莫西西林显示了最高的社区暴露水平.
- 大肠杆菌对三甲胺-硫甲醇 (90%) 和安培 (85%) 的耐药性很高.
- 耐塞法胺的大肠杆菌殖民与暴露于trimethoprim-sulfamethoxazole,cloxacillin和红色素有关.
结论:
- 地方一级的抗生素暴露估计可以澄清社区一级的耐药性模式.
- 暴露数据的时间和空间缩放对于理解耐药性至关重要.
- 这些发现可以为社区的抗生素管理计划提供信息.
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