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Updated: Jul 21, 2026

Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation
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Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation

Published on: July 8, 2011

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除了其优选的利基之外:Brucella abortus RNA在上皮细胞和内皮细胞中降低IFN-γ诱导的MHC-I表达

Agustina Serafino1, Yasmín A Bertinat1, Jorgelina Bueno1

  • 1Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas, Academia Nacional de Medicina; Buenos Aires, Argentina.

PloS one
|July 9, 2024
PubMed
概括

布鲁塞拉堕胎RNA降低了MHC-I在各种人体细胞上,帮助免疫逃避. 这种病原体RNA在戈尔吉装置中保留MHC-I,并触发细胞因子的释放,为宿主持久性提供了洞察力.

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Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
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