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黑斯佩里丁缓解了肠道屏障损伤,线粒体功能障碍和内分泌网膜线粒体接触部位在氧化应激下的障碍

Feiyang Gou¹, Qian Lin¹, Xiaodian Tu¹

¹Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Journal of agricultural and food chemistry

|July 9, 2024

概括

类植物中的一种黄类物质hesperidin,可以保护小猪免受氧化应激引起的肠道损伤. 它改善了抗氧化能力,线粒体功能和内质网膜压力,保护了肠道屏障.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
动物科学动物科学

背景情况:

氧化应激是肠道屏障损伤的主要危险因素.
类植物中的一种黄类物质hesperidin具有抗氧化特性.
赫斯佩里丁减轻氧化应激诱导的肠损伤的确切机制尚未完全理解.

研究的目的:

调查hesperidin在减轻氧化应激诱导的小猪肠道屏障损伤的潜在机制.
探索内网膜-线粒体接触点 (ERMCS) 在hesperidin的保护作用中的作用.

主要方法:

一个小猪模型的氧化应激被诱导使用diquat.
赫斯佩里丁是通过料给小猪的.
评估了生长性能,肠道屏障完整性,氧化应激标志物,线粒体功能,内质网膜 (ER) 应激和ERMCSs.

主要成果:

赫斯佩里丁缓解了暴露于二酸的小猪的生长限制和肠道屏障损伤.
赫斯佩里丁恢复了抗氧化能力,改善了线粒体功能,并通过降低PERK通路的调节来减少ER压力.
通过减少ERMCS蛋白质和改变线粒体接触动态,hesperidin使ERMCS正常化.

结论:

黑斯佩里丁可以保护小猪免受氧化压力引起的肠损伤.
赫斯佩里丁的保护作用通过缓解ERMCS障碍和预防线粒体功能障碍来调解,从而减少反应性氧物种 (ROS) 生产.
这项研究阐明了西对肠道健康的益处的新机制.

关键词:

细胞内膜网膜线粒体接触点的接触点这就是hesperidin.肠道屏障肠道屏障肠道屏障线粒体中的线粒体.氧化应激是一种氧化应激.

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