可塑性塑料 (聚烯) 可能对发育斑马鱼具有严重的毒性,并激活哺乳动物细胞中的核受体
Bryan D James1,2, Alexander V Medvedev3, Sergei S Makarov3
1Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, United States.
ACS biomaterials science & engineering
|July 9, 2024
概括
手工塑料塑料,如聚烯 (PCL) 可能是有毒的,释放有害的寡合物和纳米塑料. 热塑性聚氨 (TPU) 在斑马鱼胚胎测试中没有显示出毒性,与PCL不同.
科学领域:
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 手工可塑塑料,通常以微塑料颗粒的形式销售,在手工艺和牙科应用中很受欢迎.
- 尽管有潜在的皮肤和口腔暴露,但制造商提供的安全信息有限.
- 这些塑料可能会出未知的物质,给健康带来风险.
研究的目的:
- 评估常见的手工塑料的生物活性和毒性.
- 为了识别潜在的可漏物质及其影响.
- 挑战塑料惰性的假设.
主要方法:
- 分析了12种可塑塑料,确定了聚烯酸 (PCL) 和热塑性聚氨 (TPU).
- 使用斑马鱼胚胎测定和Attagene FACTORIAL平台评估生物活性.
- 使用 GC × GC-HRT 识别出水化合物.
主要成果:
- PCL颗粒及其液对1颗/毫升以上的斑马鱼胚胎具有急性毒性.
- 在斑马鱼胚胎测试中,TPU颗粒没有显示出毒性.
- PCL提取物激活了参与新陈代谢和氧化应激的核受体,与寡合物和纳米塑料相关的毒性.
结论:
- 基于聚烯酸 (PCL) 的可塑塑料由于释放的寡合物和纳米塑料而带来毒性风险.
- 该研究强调了与消费者使用的塑料相关的潜在危险.
- 需要进一步的研究,以确保这些广泛使用的材料的安全性.
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