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Updated: Jul 2, 2026

TIRFM and pH-sensitive GFP-probes to Evaluate Neurotransmitter Vesicle Dynamics in SH-SY5Y Neuroblastoma Cells: Cell Imaging and Data Analysis
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开发基于的探头,用于分子成像,用于大脑中突触后密度的成像

Eduardo F A Fernandes1, Mikael Palner2, Nakul Ravi Raval2,3,4

  • 1Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.

Journal of medicinal chemistry
|July 9, 2024
PubMed
概括

研究人员开发了新的分子成像探测器,准后突触密度蛋白95 (PSD-95) 以可视化大脑功能. 这些探针揭示了帕金森病患者的突触后密度受损.

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Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression09:06

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相关概念视频

Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...