埃博拉病毒疾病中的糖尿病血糖:从2018年到2020年爆发的回顾性分析
Kasereka Masumbuko Claude1, Daniel Mukadi-Bamuleka2, Kitenge-Omasumbu Richard3
1School of Medicine, Université Catholique du Graben, Butembo, Democratic Republic of the Congo; School of Public Health, University of Alberta, Edmonton, AB, Canada.
EBioMedicine
|July 9, 2024
概括
低血糖症在埃博拉病毒病 (EVD) 患者中很常见,并且与死亡率增加有关. 早期发现和治疗低血糖对于改善EVD护理结果至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 生物化学 生化学
背景情况:
- 埃博拉病毒病 (EVD) 呈现多系统器官衰竭和高死亡率.
- 严重的低血糖是重病EVD患者常见的,危及生命的并发症.
- 在埃博拉病毒治疗单元中,有限的葡萄糖监测给患者管理带来了挑战.
研究的目的:
- 调查埃博拉病毒病患者低血糖的流行率和影响.
- 分析低血糖和埃博拉病毒病死亡率之间的关联.
- 评估EVD治疗环境中的葡萄糖管理策略.
主要方法:
- 在刚果民主共和国东部接受埃博拉病毒治疗的384名患者的回顾性评估.
- 使用手持式血糖计或Piccolo xpress化学分析仪获得的葡萄糖测量.
- 分析葡萄糖水平,静脉注射乳糖和死亡率数据.
主要成果:
- 25%的患者患有严重的低血糖 (≤2.2 mmol/L),59%患有高血糖 (>10 mmol/L).
- 严重的低血糖症与2.2倍高的病例死亡率有关.
- 低血糖 (严重和中度) 是死亡率升高的重要独立预测因素 (aHR分别为6.2和3.0).
结论:
- 低血糖是EVD患者的常见和关键并发症.
- 有效的低血糖管理,包括多次静脉注射乳糖,是必不可少的.
- 解决低血糖症对于降低埃博拉疾病死亡率至关重要.
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