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Updated: Jun 21, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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基于DNA的蛋白激酶抑制剂的开发和治疗潜力

Zi Hui1, Haowen Deng2, Xuelei Zhang2

  • 1Xiangya School of Pharmaceutical Sciences, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, 410013, P. R. China; School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, P.R. China.

Bioorganic chemistry
|July 9, 2024
PubMed
概括

向对DNA修复至关重要的DNA依赖蛋白激酶 (DNA-PK) 提供了一种有希望的策略,通过破坏DNA损伤反应 (DDR) 来选择性杀死癌细胞. 本综述详细介绍了DNA-PK抑制剂的开发和临床进展.

关键词:
癌症治疗治疗 癌症治疗在DDR中,DDR是指DDR.这就是DNA-PKK.这就是为什么SAR SAR SAR.小分子抑制剂 小分子抑制剂

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