从2014年到2021年在死后样本中对新精神活性物质 (NPS) 的回顾性查
Per Ole M Gundersen1, Daniel Pasin2, Lars Slørdal3
1Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway.
Forensic science international
|July 9, 2024
概括
这项研究采用了追溯分析策略,在法医样本中识别新的精神活性物质 (NPS). 虽然该方法对一些NPS有效,但需要进一步改进才能进行可靠的检测,特别是在低度下.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物样本的回顾性分析有助于发现新的精神活性物质 (NPS) 和质量评估.
- 之前的一项研究建立了一个回顾性数据分析策略,使用一个针对合成大麻素,设计型二和合成阿片类药物的个性化库.
- 目前的研究扩展了这一策略,包括了额外的NPS类.
研究的目的:
- 应用和评估一个追溯数据分析策略,以识别在法医样本中更广泛的NPS范围.
- 评估将预测的保留时间纳入分析的有效性.
- 在死后样本中识别新型NPS和设计药物.
主要方法:
- 使用UHPLC-QTOF-MS.对2186个法医尸检样本 (2014年1月 - 2021年12月) 的回顾性处理.
- 利用了一个更新的库,包括合成的甲基,乙胺和其他NPS,预测的保留时间.
- 基于MS/MS数据可用性进行图书馆匹配的分类初步发现.
主要成果:
- 在12个样本中 (第1类) 暂定确定了5种化合物 (三种合成甲基,两种印罗基胺).
- 只有一个化合物,4-MEAPP,在案例审查后得到确认.
- 检测到501个潜在的2类发现,显著减少,但保留时间数据仍然很高.
结论:
- 追溯分析策略适用于更广泛的NPS,超出了最初研究中的NPS.
- 预测的保留时间有助于减少假阳性,但手动审查仍然具有挑战性.
- 该方法的灵敏度在检测非常低度的化合物上是有限的.
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