烧伤患者消化道的选择性去污染:系统审查的议定书
Emma Atsuko Tsuchiya1, Jacob Jensen-Abbew1, Mette Krag1,2
1Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
选择性消化道去污可能有利于烧伤患者通过减少感染和改善生存率. 这一系统性审查将分析随机试验,以评估其对死亡率和不良事件的影响.
科学领域:
- 关键护理医学 关键护理医学
- 预防传染病 预防传染病
- 烧伤患者管理管理
背景情况:
- 鼻腔感染是烧伤患者死亡和疾病的主要原因.
- 消化道的选择性去污染 (SDD) 提高了机械通风ICU患者的生存率.
- 在烧伤患者中SDD的潜在益处需要调查.
研究的目的:
- 系统地审查和对烧伤患者SDD的RCT进行元分析.
- 评估患者重要的影响,包括死亡率和不良事件.
- 评估在这个特定患者群体中SDD的证据.
主要方法:
- 随机临床试验 (RCT) 的系统审查和元分析.
- 试验顺序分析,以评估证据的确定性.
- 用GRADE方法评估建议的确定性.
主要成果:
- 主要结局:30天死亡率.
- 二次结局:严重的不良事件,抗菌素耐药性,肺炎,血液感染,ICU/不入院日,90天死亡率.
- 进行全面的数据库搜索 (CENTRAL,MEDLINE,EMBASE等). ) 的情况.
结论:
- 关于SDD在烧伤患者中的使用,存在临床均衡.
- 这次审查将评估SDD的有益和有害影响.
- 综合证据将为临床实践和未来的研究提供信息.
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