对二维碳化物 (MXenes) 的生态毒性和环境安全评估
P Abdul Rasheed1, Kashif Rasool2, Nadine Younes3
1Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, P. O. Box 34110, Doha, Qatar; Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala 678 623, India.
The Science of the total environment
|July 9, 2024
概括
这项研究评估了斑马鱼胚胎中的Nb-MXene毒性,发现分层Nb4C3Tx (DL-Nb4C3Tx) 是最有毒的. 虽然DL-Nb4C3Tx通常被认为具有低毒性,但由于其对水生生物的潜在神经毒性作用,因此需要谨慎使用.
科学领域:
- 材料科学 材料科学 材料科学
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
背景情况:
- 两维 (2D) MXenes,包括Nb4C3Tx和Nb2CTx,在水处理和生物医学领域显示出希望.
- 基于的MXenes (Nb-MXenes) 对水生有毒性的研究有限.
研究的目的:
- 使用斑马鱼胚胎,比较多层 (ML) 和分层 (DL) Nb-MXenes (Nb4C3Tx,Nb2CTx) 的急性毒性.
- 调查Nb-MXenes的潜在毒理机制和发育影响.
主要方法:
- 斑马鱼胚胎暴露在不同度的ML-Nb4C3Tx,ML-Nb2CTx,DL-Nb2CTx和DL-Nb4C3Tx中.
- 评估了急性毒性 (LC50) 和原性影响 (NOEC).
- 测量了乳酸脱酶 (LDH) 释放和超氧化离子产生,以评估细胞膜损伤和氧化应激.
主要成果:
- 分层Nb4C3Tx (DL-Nb4C3Tx) 显示出最高的死亡率 (LC50 = 128 mg/L) 和致性影响 (NOEC = 100 mg/L).
- 与DL-Nb4C3CTx相比,DL-Nb4C3Tx诱导的细胞膜损伤和超氧化离子产生更大.
- 两种DL-Nb-MXene类型都表现出潜在的神经毒性作用,证据是暴露的斑马鱼胚胎中的超位移.
结论:
- 所有测试的Nb-MXenes都根据FSW尺度被归类为"几乎无毒".
- DL-Nb4C3Tx对水生生物构成更高的风险,特别是在神经毒性方面,即使度低于"实际上无毒"值.
- 需要进一步的研究来了解Nb-MXenes,特别是DL-Nb4C3Tx在水生生态系统中的长期环境影响.
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