青少年口服氧化自我管理会破坏神经行为和神经认知发育
Kristen A McLaurin1, Rachael K Ott2, Charles F Mactutus2
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40508, USA.
Neuropharmacology
|July 9, 2024
概括
青少年氧化 (OXY) 自给药会损害神经行为和神经认知发育,导致持久的注意力缺陷. 这凸显了为青少年滥用处方阿片类药物制定更安全的处方指南的需要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 非医疗处方阿片类药物的使用在青春晚期普遍存在,这是认知发展的关键时期.
- 慢性青少年氧化 (OXY) 自给药对神经行为和神经认知功能的影响仍未得到充分研究.
研究的目的:
- 为了研究青少年口服氧化自我给药对大鼠神经行为和神经认知发育的剂量依赖性影响.
- 为了确定青少年氧化暴露在戒烟后对认知功能的长期影响.
主要方法:
- 青少年大鼠 (产后35-105天) 通过两瓶选择范式在10周内获得口服氧化 (0,2,5或10毫克/公斤) 或水.
- 神经行为评估包括运动和惊反应能力;神经认知功能使用前脉冲抑制和持续注意力任务进行评估.
- 一个纵向设计跟踪了慢性氧化自给期间和之后的效果.
主要成果:
- 无论性别或剂量,老鼠自愿增加了氧化的摄入量.
- 氧化暴露导致了剂量依赖的运动能力增加和性依赖的惊反应能力增加.
- 停止后观察到注意力处理和持续注意力的长期缺陷,而刺激增强学习没有受到影响.
结论:
- 慢性青少年氧化自给药会导致神经行为和神经认知发育的显著,长期的改变.
- 这些发现强调了与青少年阿片类药物滥用相关的神经发育风险.
- 建议为使用处方阿片类药物的青少年提供更安全的处方指南.
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