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Updated: Jun 21, 2025

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
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Published on: March 15, 2019

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CoRAL精确地解决了长时间读取序列的染色体外DNA基因组结构

Kaiyuan Zhu1, Matthew G Jones2, Jens Luebeck1

  • 1Department of Computer Science and Engineering, University of California San Diego, La Jolla, California 92093, USA.

Genome research
|July 9, 2024
PubMed
概括

使用长读数的扩增完全重建 (CoRAL) 准确地重建了染色体外DNA (ecDNA) 结构,改进了癌症基因扩增分析. 这种方法提高了对瘤进化和药物耐药性机制的理解.

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