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Updated: Jun 21, 2025

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
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Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Published on: January 7, 2019

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没有结合的未折叠蛋白质反应的ER procollagen储存缺陷驱动早期关节炎

Kathryn M Yammine1, Sophia Mirda Abularach1, Seo-Yeon Kim1

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.

Life science alliance
|July 9, 2024
PubMed
概括

原体II型折叠的缺陷会导致内质网膜储存障碍,导致骨关节炎. 这项研究描述了一种干细胞软骨模型,以了解疾病机制,并测试对原蛋白病变的治疗方法.

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