在BCG诱导的训练免疫的季节性变化
Gizem Kilic1, Priya A Debisarun1, Ahmed Alaswad2
1Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Vaccine
|July 9, 2024
概括
冬季BCG疫苗接种比春季疫苗接种更有效地增强训练免疫力,导致更强的先天免疫反应和表观遗传重编程,特别是在NK细胞中.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 时间生物学 时间生物学
背景情况:
- 细菌卡尔梅特 - 格林 (BCG) 疫苗诱导训练免疫力,增强先天免疫反应.
- 众所周知,季节性变化会影响先天免疫力,但它们对BCG诱导的训练免疫力的影响仍然未被探索.
研究的目的:
- 调查疫苗接种季节 (冬季与春季) 对BCG诱导的训练免疫的影响.
- 分析BCG接种后免疫细胞中的ex vivo细胞因子反应,基因表达和表观遗传特征.
主要方法:
- 健康的志愿者在冬季或春季接受BCG疫苗接种.
- 接种疫苗后三个月,对外围血液单核细胞 (PBMC) 和NK细胞进行了分析,以检测细胞因子的产生,基因表达和表观遗传修饰.
- 反应与基线和疫苗接种组之间的反应进行了比较.
主要成果:
- 与春季疫苗接种相比,冬季BCG疫苗接种在PBMC中诱导了更强的促炎细胞因子反应.
- 来自冬季接种疫苗的人的NK细胞显示出增强的促炎性细胞因子和IFNγ生产能力.
- 在单细胞和NK细胞中发现了依赖季节的表观遗传变化,与冬季组中免疫细胞反应性增强相关.
结论:
- 冬季的BCG疫苗接种促进了比春季疫苗接种更强大的训练免疫反应.
- 季节性时间影响BCG激活和表观遗传性重编程免疫细胞的能力,特别是NK细胞.
- 结果表明,优化疫苗接种时间,以增强先天免疫记忆诱导.
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