患有急性肺栓塞的癌症患者的初始血液动力学状态和急性死亡率:来自COMMAND VTE注册表
Wei Xiong1,2, Yugo Yamashita3, Takeshi Morimoto4
1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Journal of thrombosis and thrombolysis
|July 9, 2024
概括
患有活跃癌症的患者从肺栓塞 (PE) 开始的血液动力学功能障碍较少,但面临着类似的PE相关死亡风险和更高的整体死亡率. 对这个群体来说,谨慎的管理至关重要.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 关键护理医学 关键护理医学
背景情况:
- 最初的血液动力学状态对于急性肺栓塞 (PE) 结果至关重要.
- 关于PE患者活跃癌症的血液动力学功能障碍和死亡率存在争议.
研究的目的:
- 为了比较PE患者的初始血液动力学功能障碍,管理和30天死亡率,有或没有活跃的癌症.
主要方法:
- 来自COMMAND VTE注册表的1715名PE患者的分析.
- 血液动力学状况,治疗策略和30天死亡率结果的比较.
- 将患者分为活跃癌症 (N=393) 和没有活跃癌症 (N=1322) 的两组.
主要成果:
- 活跃癌症患者的右心室功能障碍 (35.4%vs49.5%),休克 (6.4%vs11.6%) 和心脏骤停 (1.8%vs5.5%) 的比例较低.
- 活跃的癌症患者接受的系统性血栓溶解较少 (4.1%对12.6%).
- 在30天PE相关死亡没有显著差异 (4.1%对4.2%);在活跃癌症患者中,30天所有原因死亡率较高 (11.5%对4.9%).
结论:
- 活跃癌症的PE患者最初的血液动力学功能障碍较少.
- 尽管PE特异性死亡率相似,但活跃癌症患者的整体死亡率更高.
- 对于患有活跃癌症的PE患者来说,无论最初的血液动力学状况如何,谨慎管理是必不可少的.
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