与高身体活动水平相关的静脉血栓栓塞的风险在27岁以上的男性中随访
P Wändell1, M A Enarsson2, T Feldreich3
1Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden. per.wandell@ki.se.
高度体力活动 (PA) 可能会增加静脉血栓塞栓症 (VTE) 的风险,这是一个常见的心血管疾病. 这项研究发现,与PA水平最低的男性相比,PA水平最高的男性的VTE风险明显更高.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 静脉血栓塞栓症 (VTE) 是一种重要的心血管疾病.
- 之前的研究表明,身体活动 (PA) 与VTE风险之间的关联显示出不同的结果.
- 对这种关系的全面理解对于公共卫生指南至关重要.
研究的目的:
- 调查身体活动水平与静脉瘤发病率之间的关联.
- 分析随着时间的推移在纵向队列中更新的PA数据.
- 在分析中调整已确定的心血管风险因素.
主要方法:
- 利用了来自乌普萨拉长度研究成年男性 (ULSAM) 队列的数据.
- 在50,60,70和77岁时通过问卷收集休时间的PA数据.
- 采用了考克斯回归分析,更新了事件VTE的共变量和危险比率 (HRs).
主要成果:
- 在68,263人年的随访期间,共发生了186起VTE事件.
- 具有最高PA水平的男性表现出VTE的相对风险增加 (调整HR,2.22).
- 当将最高的PA组与最低的PA组进行比较时,观察到这种风险增加.
结论:
- 较高水平的体力活动,包括劳累性活动,可能与男性风险增加有关.
- 这些发现表明,在VTE预防的背景下,可能需要重新评估PA建议.
- 需要进一步的研究来阐明这种关联背后的机制.
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